The liver is a vital organ for maintaining life. Its functions are so diverse and complex that there is no artificial device that can replace it. Therefore, the only way to treat patients with end-stage liver diseases is liver transplantation. Liver transplantation is a surgical procedure that removes the afflicted liver and replaces it with a healthy one. Liver transplantation first began in the United States in 1963, followed by Korea in 1988, and by AMC in 1992. AMC had succeeded the first pediatric living donor liver transplantation in 1994, and the first adult living donor partial liver transplantation in 1997. Since then, AMC has been actively performing liver transplantations.